{"id":396,"date":"2022-07-25T15:11:35","date_gmt":"2022-07-25T13:11:35","guid":{"rendered":"https:\/\/oncoact.nl\/?page_id=396"},"modified":"2026-08-07T13:10:19","modified_gmt":"2026-08-07T11:10:19","slug":"treating-physician","status":"publish","type":"page","link":"https:\/\/oncoact.nl\/en\/treating-physician\/","title":{"rendered":"Treating Physician"},"content":{"rendered":"\n<div class=\"wp-block-columns background-lightgray is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<h2 class=\"wp-block-heading\">What do you know after the comprehensive DNA test?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The comprehensive DNA test is used to reveal the complete DNA of the tumor. This involves a single, validated diagnostic test (OncoAct) using only one freshly frozen tissue sample and a blood control sample as input.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">We identify four types of abnormalities: mutations, amplifications, fusions and loss of genes.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In addition to the standard abnormalities, the test can provide information about the presence of specific molecular profiles such as homologous recombination deficiency and microsatellite instability, as well as reveal the total number of tumor mutations.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">We only report back abnormalities (mutations\/biomarkers) that are potentially actionable and may be relevant for treatment decisions.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Watch the short video we have created for physicians and pathologists.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\"><div class=\"nocookie-youtube\">\r\n  <figure class=\"embed-responsive embed-responsive-16by9\">\r\n    <iframe class=\"embed-responsive-item\"\r\n      src=\"https:\/\/www.youtube-nocookie.com\/embed\/d_6S97tZDkc?rel=0\" allowfullscreen><\/iframe>\r\n  <\/figure>\r\n<\/div><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h2 class=\"wp-block-heading\">Why use WGS for DNA Testing in the Care of Patients with Cancer?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The treatment of cancer is increasingly based on molecular characteristics of the tumor, which are different for each patient. In order to determine which medication best suits the patient, it is essential to know which mutations can be found in the DNA of the tumor. Once the entire DNA sequence of the tumor has been examined, all the biomarkers found can be used to assess whether there is any medication available for treating this specific tumor (targeted medication).<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h2 class=\"wp-block-heading\">Personalized Treatment<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">With the growing number of targeted medications available, it is becoming increasingly possible to provide personalized treatment. Treatment is then based on all the individual characteristics of the patient\u2019s tumor. This work method increases the chance that the patient gets the right medication. It reduces the risk of over treatment with ineffective drugs and prevents the associated unpleasant side effects. \u201cPersonalized\u201d treatment may simply be standard treatment.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h2 class=\"wp-block-heading\">Taking the Biopsy Sample<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">In order to be able to conduct this DNA test properly, high standards are set for the collection of tumor tissue and blood as well as for how they are transported. The biopsy sample should be frozen as soon as possible and not set. The instructions for the hospital The instructions for this process can be found in the registration module of the online customer portal.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group background-lightgray\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h2 class=\"wp-block-heading\">Biomarker Detection<\/h2>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"wp-block-paragraph\">Not only the number, but also the complexity of biomarkers has increased significantly in recent years. In order to always report the latest insights without having to set up new DNA tests, we use&nbsp;<a href=\"https:\/\/oncoact.nl\/how-does-oncoact-work\/?lang=en#wholegenomesequencing\"><em>whole genome sequencing<\/em><\/a>. It can detect any possible DNA-based biomarkers. This technique requires not only the DNA of the tumor, but also the \u201cnormal\u201d DNA of the patient in order to see which DNA changes determine the origin of the tumor. In addition to the tumor tissue, blood must also be taken.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Different DNA tests are performed in the current diagnostics. These look at a limited part of the DNA. OncoAct is a software&nbsp;developed by Hartwig Medical Foundation&nbsp;that analyses WGS data for cancer diagnostics and treatment decision making purposes.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"wp-block-paragraph\">Here are just some of the properties that OncoAct can determine:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>mutations in oncogenes, including activation of kinases<\/li>\n\n\n\n<li>bRAF mutations in skin and lung cancer<\/li>\n\n\n\n<li>ALK, ROS1, RET, fusion genes in lung cancer<\/li>\n\n\n\n<li>EGFR mutations and exon skipping in lung cancer<\/li>\n\n\n\n<li>EGFR resistance mutations in lung cancer<\/li>\n\n\n\n<li>MET amplification and exon 14 splice mutations in lung cancer<\/li>\n\n\n\n<li>HER2 mutations in breast and lung cancer<\/li>\n\n\n\n<li>RAS status in colon cancer<\/li>\n\n\n\n<li>NTRK1, 2, 3 fusions<\/li>\n\n\n\n<li>microsatellite instability (MSI)<\/li>\n\n\n\n<li>tumor mutational burden (TMB)<\/li>\n\n\n\n<li>BRCA1\/2 mutations in ovarian and breast cancer<\/li>\n\n\n\n<li>homologous recombination deficiency (HRD, \u201cBRCAness\u201d) in ovarian and breast cancer<\/li>\n\n\n\n<li>HER2 amplification and PIK3CA status in breast cancer<\/li>\n\n\n\n<li>PDGFRA and cKIT mutations in gastrointestinal stroma tumors (GIST), etc.<\/li>\n\n\n\n<li>IDH1 and IDH2 mutations and EGFRvIII status in brain tumors<\/li>\n\n\n\n<li>detection of fusion genes in soft tissue tumors<\/li>\n\n\n\n<li>all founder mutations for clonality studies (e.g. TP53, APC).<\/li>\n<\/ul>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"wp-block-paragraph\">The OncoAct WGS report is updated immediately when new biomarkers become available that may be relevant to a treatment choice. The advantage of&nbsp;<a href=\"https:\/\/oncoact.nl\/how-does-oncoact-work\/?lang=en#wholegenomesequencing\"><em>whole genome sequencing<\/em><\/a>&nbsp;is that you do not have to modify or validate the DNA test itself. Adjusting the software will suffice. This means that the DNA test is always up to date with the most recent insights. The OncoAct WGS report also refers to experimental treatments that are available and to \u201coff-label\u201d options in the&nbsp;<a href=\"https:\/\/www.cpct.nl\/studie-info\/\">DRUP study<\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In addition to DNA diagnostics, other test results are also important. These tests are performed by the pathology, clinical chemistry, and radiology departments of the hospital. Other patient characteristics may also play a role.<\/p>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-columns background-blue is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><div class=\"block-quotes\">\r\n\r\n        \r\n    <div class=\"container\">\r\n    <div class=\"row align-items-center justify-content-center\">\r\n      <div class=\"col-lg-7\">\r\n        <img loading=\"lazy\" decoding=\"async\" width=\"833\" height=\"833\" src=\"https:\/\/oncoact.nl\/wp-content\/uploads\/2022\/07\/Emile-Voest.jpg\" class=\"quote-photo\" alt=\"\" srcset=\"https:\/\/oncoact.nl\/wp-content\/uploads\/2022\/07\/Emile-Voest.jpg 833w, https:\/\/oncoact.nl\/wp-content\/uploads\/2022\/07\/Emile-Voest-300x300.jpg 300w, https:\/\/oncoact.nl\/wp-content\/uploads\/2022\/07\/Emile-Voest-150x150.jpg 150w, https:\/\/oncoact.nl\/wp-content\/uploads\/2022\/07\/Emile-Voest-768x768.jpg 768w\" sizes=\"auto, (max-width: 833px) 100vw, 833px\" \/>        <div class=\"quote\">\n<p class=\"wp-block-paragraph\">\u201cEvery patient with metastatic cancer should be given the opportunity to get the whole tumor genome examined once for the best chance of a working treatment.&#8221;<\/p>\n<\/div>\r\n        <div class=\"quote-author\">\r\n          &mdash; Emile Voest<br \/>\r\n          <span>INTERNIST\/ONCOLOGIST ANTONI VAN LEEUWENHOEK<\/span>\r\n        <\/div>\r\n      <\/div>\r\n    <\/div>\r\n  <\/div>\r\n    <\/div><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group background-darkgray\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"wp-block-paragraph\">Hartwig Medical OncoAct\u00ae<\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column mr-auto is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:35%\">\n<h2 class=\"wp-block-heading\">OncoAct<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">OncoAct, Hartwig Medical Foundation\u2019s most comprehensive molecular diagnostic DNA test, is suitable for all adult patients with cancer who have tumor tissue that can safely be collected. OncoAct is suitable for all types of cancer, except leukemia.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:25%\">\n<h2 class=\"wp-block-heading\">Current Molecular Diagnostic DNA Tests<\/h2>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\">In the current care of patients with cancer, hospitals already conduct various molecular diagnostic DNA tests. These DNA tests focus on a limited number of DNA characteristics of the tumor. They are therefore suitable for a limited number of types of cancer.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:25%\">\n<h2 class=\"wp-block-heading\">Off-Label Treatment Options<\/h2>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\">OncoAct can, in certain cases, identify additional experimental treatment options.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The following patients can benefit most from the complete DNA test:<\/p>\n\n\n\n<ul id=\"norebro-custom-63f36c19ea2bf\" class=\"wp-block-list\">\n<li>patients who no longer have any treatment options available based on regular diagnostics<\/li>\n\n\n\n<li>patients with a rare tumor (approximately 23,000 patients in the Netherlands) who have no standard treatment available to them.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">The treating physician and patient decide together whether OncoAct should be requested.<\/p>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-columns background-lightgray is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><div class=\"block-quotes\">\r\n\r\n        \r\n    <div class=\"container\">\r\n    <div class=\"row align-items-center justify-content-center\">\r\n      <div class=\"col-lg-7\">\r\n        <img loading=\"lazy\" decoding=\"async\" width=\"801\" height=\"801\" src=\"https:\/\/oncoact.nl\/wp-content\/uploads\/2022\/07\/Behandelaar-Niven-Mehra-vvbvanbree-squre.jpg\" class=\"quote-photo\" alt=\"\" srcset=\"https:\/\/oncoact.nl\/wp-content\/uploads\/2022\/07\/Behandelaar-Niven-Mehra-vvbvanbree-squre.jpg 801w, https:\/\/oncoact.nl\/wp-content\/uploads\/2022\/07\/Behandelaar-Niven-Mehra-vvbvanbree-squre-300x300.jpg 300w, https:\/\/oncoact.nl\/wp-content\/uploads\/2022\/07\/Behandelaar-Niven-Mehra-vvbvanbree-squre-150x150.jpg 150w, https:\/\/oncoact.nl\/wp-content\/uploads\/2022\/07\/Behandelaar-Niven-Mehra-vvbvanbree-squre-768x768.jpg 768w\" sizes=\"auto, (max-width: 801px) 100vw, 801px\" \/>        <div class=\"quote\">\n<p class=\"wp-block-paragraph\">\u201cYou want to start the most effective therapy as early as possible for some aggressive types of cancer, and sometimes this can be done by understanding the molecular background of that particular patient&#8217;s cancer.\u201d<\/p>\n<\/div>\r\n        <div class=\"quote-author\">\r\n          &mdash; Niven Mehra<br \/>\r\n          <span>MEDICAL ONCOLOGIST RADBOUDUMC NIJMEGEN<\/span>\r\n        <\/div>\r\n      <\/div>\r\n    <\/div>\r\n  <\/div>\r\n    <\/div><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>What do you know after the comprehensive DNA test? The comprehensive DNA test is used to reveal the complete DNA &hellip;<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-396","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Treating Physician - Hartwig Medical OncoAct<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/oncoact.nl\/en\/treating-physician\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Treating Physician - Hartwig Medical OncoAct\" \/>\n<meta property=\"og:description\" content=\"What do you know after the comprehensive DNA test? 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