English 
NederlandsHow Do I Request OncoAct?
OncoAct can only be requested by a treating physician in a hospital. Tissue logistics should be coordinated with the hospital’s pathology department. Before tumor tissue and blood can be transported, a Service Agreement must be signed.
Service Agreement
The treating physician:
Requests
First requests a OncoAct Service Agreement via email.
Completes
Electronically completes the Service Agreement entirely and correctly.
Submits
Submits the Service Agreement by email to Hartwig Medical Foundation for verification.
Receives the Service Agreement
Will receive the Service Agreement by email after it has been verified and signed by Hartwig Medical Foundation, in order for it to be signed by the appropriate persons at the hospital.
Signs the agreement at the hospital
Scans the signed Service Agreement and sends it to Hartwig Medical Foundation by email.
Transport of Tumor Tissue and Blood
The treating physician:
Receives the Sample Registration Form
Will receive a Sample Registration form for tumor tissue and blood after Hartwig Medical Foundation and the appropriate people in the hospital sign the Service Agreement. It contains the pre-assigned ID number for the tumor tissue and blood. This ID number is used by Hartwig Medical Foundation and mentioned in the OncoAct patient report.
Anonymous ID Number
Can add their own anonymous ID number on the registration form to appear on the patient report, for internal linking.
Receives Information from Hartwig Medical Foundation
Completes the Sample Registration form entirely and correctly (Tab 1). Receives information from Hartwig Medical Foundation about the collection of tumor tissue and blood (Tabs 2 and 3).
Sends a Digital Copy of Sample Registration Form to Hartwig Medical Foundation
Sends a digital copy of the completed Sample Registration form to Hartwig Medical Foundation.
Sending the Tumour Tissue and Blood
Sends tumor tissue via the pathology department and blood via the phlebotomy outpatient clinic to Hartwig Medical Foundation according to instructions along with both the printed and fully completed Sample Registration forms.
Confirms Receipt
Will receive an acknowledgement of receipt by email with a registration number after receipt of tumor tissue and blood. Hartwig Medical Foundation requests the registration number to be used in all further correspondence.
DNA Analysis and Report
Hartwig Medical Foundation:
Extensive DNA test
Begins processing tumor tissue and blood, performs the sequencing and analysis, and records the findings in a patient report.
Patient Report
Sends the patient report (digitally) to the treating physician, if the tumor tissue and blood are of sufficient quality, within two to three weeks.
Would you like to know more about the extensive DNA test? Visit: How does OncoAct work?
Costs and Reimbursement
OncoAct costs €4,200 excluding VAT. This includes all activities, from receiving the tumor tissue and blood to compiling and sending the patient report. This includes a summary (explanation) of the findings of the clinical molecular biologist for the treating physician and patient.
Each country has its own rules for the reimbursement of molecular diagnostic DNA tests, including OncoAct. The Netherlands does not charge a separate fee for DNA tests like OncoAct, but hospitals do receive a budget for performing (molecular) diagnostic DNA tests like OncoAct.
For the patient: You can ask your health insurer and healthcare provider in your own country whether they will reimburse part of the DNA test or whether the hospital where the DNA test is taken will bear the costs independently.
If it turns out that the tumor percentage in the tumor tissue is lower than 20%, the data are insufficiently reliable for performing a bioinformatic data analysis. If that happens, we will not compile a patient report. In that case, we will only charge the costs for the processing of the tumor tissue and blood and the initial quality controls. These amount to €500 excluding VAT.
Request a DNA test via the attending physician: We only work at the request of the treating physician. In order to provide OncoAct, we always enter into a Service Agreements with the healthcare institution. By doing this, we ensure that the biopsy and blood collection is done via the pathology department and the phlebotomy outpatient clinic and that the results of the DNA test are also included in the patient file and are available for treatment and inspection.
More Information
If you are a treating physician and you have further questions after reading the above information, please email info@oncoact.nl. You can also contact us by phone on working days via +31 (0)20 – 235 2640.
“WGS offers the possibility to implement new biomarkers directly. This way you always have the most complete genomic analysis.”
— Kim Monkhorst
Pathologist Antoni van Leeuwenhoek